URI Sticky?

Pardon my newbie nature, but is there any way to implement URI stickiness via iRules? I don't think I've ever seen a load balancing technology that cannot handle this, but I'm having a devil of a time figuring out how to do this with F5.

 

 

As you might guess, this is for a scenario with resource-limited caching on each node. Once a URI has been requested and cached, I'd like all subsequent requests for that URI to go to the same node.