Nimbostratus
MVPHi Kazeem,
basically you have to check the entire service chain between your client and the pool servers.
Check if the client does forward the request to your proxy? It could be that a PROXY.PAC file has excluded the URL so that the client tries a direct connection to your site.
If the client does send the request to your proxy, then report the error message the proxy is responding. It contains most likely additional information (e.g. DNS errors, Network timeouts, etc.) why the connection can't be established.
If this doesn't help, then you have to access the proxy servers and troubleshoot the connection between the individual proxys and your VIP. Either open a browser on those server or use telnet to probe if the destination IP:Port is reachable (connection can be established). If this fails, then consult the firewall logsfiles and/or review your routing infrastructure for possible asymetric routings.
If the proxy can establish a connection to your VIP but it can't receive a valid response, then check if asymetric routings exist on the way back from the pool members to the proxy servers. Could be a SNAT problem somehow...
Cheers, Kai